The role of microRNA-32 in hepatocarcinoma / 国际肿瘤学杂志

MicroRNAs (miRNA)play an important role in a variety of cellular biology processes,and participate in the occurrence and development of a variety of diseases including hepatocellular carcinoma (HCC).In recent years,miR-32 has been shown to be aberrantly expressed in many tumor tissues.miR-32 is up-regulated in HCC and plays an oncogene role in regulating the cell cycle,apoptosis,invasion,metastasis and so on.MiR-32 maybe a potential target for HCC therapy.

Clearance effect of milk containing anti-Helicobacter pylori specific antibody:a randomized clinical trial / 中国免疫学杂志

Objective:To compare and observe the different clearance effect of milk containing anti-Helicobacter pylori specific antibody. Methods:Four H. pylori strains were used to immune dairy cows to obtain milk containing anti-Helicobacter pylori specific antibody,of which,one was standardized strain and the other three were locally epidemic. Totally 148 people were screended,in which 72 were C-14 urea breath test positive, finally 39 meet the criteria. They were divided into two groups, the test group contained 21 subjects,were treated milk containing anti-Helicobacter pylori specific antibody;the 18 subjects in control group with common milk. The study was continued for 2 months. Results:Conducting the C-14 urea breath test,9 subjects in test group were negative,but no one was changed in control group. The effective clearance rate of the test group was 42. 86%,and there was no effective clearance in the control group,so there was significant difference in the two groups(P=0. 005,P<0. 05). Conclusion: The milk containing anti-Helicobacter pylori specific antibody is polyclonal and has higher valence,and could clear H . Pylori effectively.

The efficacy evaluation of common antineoplastic drugs in TACE for primary hepatic carcinoma / 实用肿瘤学杂志

Transarterial chemoembolization is an important treatment for advanced primary hepatic carci -noma.Along with the development of TACE therapy , more and more antineoplastic drugs have been used in transarterial chemoembolization .However,the side effects and the efficacy of the drugs are still not very clear . Therefore,we summarize and compare the mechanism of actions ,efficacies and side effects of these drugs in this paper .